Polynucleotides
Explore the Power of Polynucleotides at The Calla Clinic in Derbyshire
At The Calla Clinic we are always ahead of the game. We have been using injectable polynucleotides in our practice for over two years and they have been taking the world by storm.
From Jennifer Aniston, to Kim Kardashian- there are a whole host of celebrities having the ‘salmon-sperm facial’ treatment for the restorative, anti-aging benefits.

At a glance
15 – 30 minutes
6 – 12 months
3 – 6
2 – 7 days
Mild


Why Choose The Calla Clinic for your Polynucleotide Treatment?
Not all polynucleotides are equal- the quality & concentration of the polynucleotide is crucial for achieving optimal results.
There are lots of brands out there that contain doses as low as 2 mg per treatment, which is considerably lower than the dosing we use (40mg per ml). This is relevant because the higher the concentration of polynucleotide injected into the skin the better the result. Don’t be fooled by brands offering cheap polynucleotide treatments- this is usually the reason.
So, what are polynucleotides and how can they help your skin?
Polynucleotides are long chains of nucleotides, which are the building blocks of DNA and RNA in all living things. They are naturally found in our cells and help with cell regeneration and repair. They work by instructing your skin to behave in a more effective way, protect your skin from damage and support hydration.
Here’s how they work:
- Cellular Repair: Polynucleotides provide the skin with the building blocks to repair damaged DNA in cells, promoting healthy cell function. This is especially helpful in reversing damage caused by aging, sun exposure, or pollution.
- Stimulating Collagen Production: Collagen is a protein that keeps the skin firm and elastic. Polynucleotides help stimulate fibroblasts, the cells responsible for collagen production. This leads to increased collagen levels, improving skin elasticity and reducing fine lines and wrinkles.
- Increasing Hydration: Polynucleotides have hydrophilic (water-attracting) properties, meaning they can retain moisture in the skin. This results in better hydration, which is key to plumper, smoother, and healthier-looking skin.
- Anti-inflammatory and Healing Properties: Polynucleotides also reduce inflammation and support tissue repair. This can help improve conditions like redness or irritation and accelerate the healing of damaged or stressed skin.

By targeting these key factors—repair, hydration, collagen production, and inflammation control—polynucleotides can effectively rejuvenate the skin, making it look younger and healthier.
Indeed, a clinical study of patients treated with polynucleotides found that, after 20 weeks, hydration had improved by 115% and elasticity had increased by 38%.
FAQs
How do polynucleotides compare to dermal filler treatment?
You may wonder which treatment is most suitable for you. Perhaps you are considering dermal filler treatment but also like the sound of polynucleotides? Well, these two treatments offer very different benefits and can be effectively used together to achieve the best results for you.
Dermal filler treatment is designed to restore volume loss, reduce hollowing, add definition and structure. Polynucleotides on the other hand are used to improve your skin quality by helping boost collagen and prevent on-going skin damage. They can be an effective tool to combine with filler treatment to ensure you look refreshed, natural and don’t neglect the health of your skin.
Can polynucleotides refresh my tired under eyes?
Yes – polynucleotides are a fantastic treatment option to help refresh the under eye area. The skin in your under eye area typically shows the first signs of ageing as it is thin and more delicate. This leads to dark circles as you can visibly see the underlying muscles and blood vessels through the skin. You may also experience puffiness and fine lines. Polynucleotides are the perfect treatment for this area as they will not worsen puffiness, will help support the skin quality and provide on-going antioxidant protection for the delicate skin. Often dermal fillers are not suitable for the under eye area and in these cases polynucleotides are a safe, effective alternative.
Is the treatment safe?
Yes, polynucleotide injections are a very safe and effective treatment. They are a naturally occurring substance in the body, so the risk of an adverse reaction such as allergy is very low. As with all medical aesthetic treatments, there are always small risks, such as infection, which will be discussed with you during your consultation.
How long do the results last?
The results of polynucleotide treatments typically last around 6 to 12 months depending on individual factors like skin condition, age, and lifestyle. After the initial treatment series, maintenance sessions may be recommended every 6 to 12 months to sustain the results. Polynucleotides work gradually by stimulating collagen production and improving skin health, so the effects can continue to improve over time before eventually requiring follow-up treatments.
Let’s chat
jack anthony2024-10-19 Thank you very much to Nurse Cheryl and Teresa for An incredible service. I went in for a facial, which was quite honestly one of the best I have ever had. Thank you very much for looking after me and for your incredible hospitality. I will definitely be coming back for more treatments. Highly recommend! Hayley Allen2024-10-11 I have been going to the calla clinic for a year now… I feel completely safe with Harriet and Cheryl. They are both medical professionals which for me was an essential requirement. They are both passionate and knowledgeable about their business and were able to reassure an initially nervous me, explain treatments so that I could make an informed decision. I love the results from my treatments and now feel happier with my face and more confident. From the moment you walk through the door Ellie makes you feel at home and welcomed - a really lovely space that I enjoy visiting. Sangita Dosanjh2024-06-27 A pleasurable visit began on entering the building , to be met by a friendlly receptionist . A professional in depth explanation of skin products to optimise long term care skin care. Wide availability of skin enhancing procedures delivered by Dr.Harriet in a relaxed , and unpressurised environment . Hardeep Kooner2024-06-18 Lovely Clinic and lovely staff always feel welcomed. Dr Harriet is very thorough with the skincare advice and the treatment. Highly recommended. anne2024-05-29 The staff are knowledgeable and friendly I was put ease and my procedure was thoroughly explained. I have wasted a lot of money on skin care products over the years that didn’t work. I wish I had known how easy it was to attend a skin clinic for help and advice. My skin improved in weeks. I can thoroughly recommend the calla clinic and their lovely staff. Julie Purnell2024-02-29 Really glad that I tried the Calla Clinic, I was put at ease straight away and was recommended the right treatment to achieve the result I wanted. The treatment was explained clearly by Dr.Harriet and adjustments made to what was more suitable for me. A lovely friendly team and great experience, would highly recommend Lyndsey McCabe2023-12-05 5* professional service. Very welcoming. Will never go anywhere else again!!! Thank you Sally2023-12-02 Have been having various treatments by Cheryl for over 15 years and she is the best and believe me I’m a challenge! She is a perfectionist and can’t recommend her highly enough, I’ve had some terrible experiences beforehand and she has worked marvels. Cheryl never stops learning of the the latest advanced treatments at the forefront of her field and you can be rest assured you get the best and why people but there faith in charlatans out there offering cheap treatments with minimal training is baffling to me so I say to you anyone out there if you want the best then ‘The Calla Clinic’ is it and if I could rate it more stars I would.